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Darmstadt, Germany
TU Darmstadt | Theoretische Anorganische ChemieKrewald Research Group: Theoretical Inorganic Chemistry
Our research goal is to understand the electron structure and functioning of inorganic complexes by methods of quantum chemistry. In order to link experiment and theory as closely as possible, we make predictions about the spectroscopic, magnetic and other measurable properties of transition metal complexes.
We are particularly interested in systems that have unexpected properties, are magnetically coupled, can achieve difficult molecular transformations or show promising catalytic activity.
Darmstadt, Germany
TU Darmstadt | Renewable resources and nanoporous materialsOur research focuses on the interdisciplinary development of innovative catalysis technologies and processes for the utilization of renewable resources as well as on exploiting the potential of nanoporous materials in catalysis and separation.
Darmstadt, Germany
TU Darmstadt | Technische ChemieIn the etzoldlab
In the etzoldlab the challenges arising with the needed global energy change and future sustainable feedstock supply for chemical industry are the major research guideline. From the perspective of chemical engineering, a multidisciplinary approach is employed to provide scientific solutions for these challenges, especially for the complex interplay of catalytic materials within a full process or device. In the scientific approach, generic experiments play a dominant role. They allow controlling process conditions from highly idealized towards technically realistic and are combined with diagnostics providing in-situ information. Chemical reaction engineering simulations complement the experiments, giving especially insights into complex mass transfer phenomena and, therefore making a more holistic picture possible. As a future sustainable energy and chemical industry will need a concerted interaction of electrochemical and classical heterogeneous catalyzed processes both are studied. Based on this strategy, the research of the etzoldlab can be divided in three strongly interacting sub-groups: Advanced Catalytic Materials – Electrochemical Energy Conversion Processes – Heterogeneous Catalysis and Processes. More details on the research of these subgroups can be found in the sections below.

With our research we are part of the following huger or collaborative research activities:

Profile Area Thermo-Fluids & Interfaces
Profile Area Future Energy Systems
Profile Area Vom Material zur Produktinnovation
Darmstadt, Germany
TU Darmstadt | PolymerisationstechnikThe close connection between simulation and experiment is a strong concern for us in every project. We thus offer a diverse field of work that combines kinetics, simulation, high-pressure and polymerization technology, as well as the design of new microstructural properties of polymers.
Darmstadt, Germany
TU Darmstadt | MedizinalchemieMedicinal Chemistry
Molecular mechanisms of neurodegenerative diseases: Alzheimer's dementia, BSE
Protein aggregation: amyloid beta, tau, prions
Enzyme inhibition: aspartyl proteases (Alzheimer's dementia), 20 S proteasome (oncology)
Organic synthesis
in ionic liquids
Aromatic heterocycles
Peptide Mimetics
Darmstadt, Germany
TU Darmstadt | Organische ChemieResearch focus
Our current research projects in the field of bioorganic and synthetic chemistry aim at the development of efficient chemo-enzymatic methods for the preparation of chiral, biologically active compounds. This includes the

development of new biocatalytic syntheses
We use native and recombinant enzymes to synthesize bioactive natural products as well as structurally related non-natural mimetics with potential bioactivity. A primary aspect is the use of enzymes as the exclusive chiral element to drive asymmetric induction. A particular focus is on biocatalytic asymmetric CC bond linkage, specifically by enzymes from carbohydrate metabolism.

Development of new enzyme catalysts
The overproduction of novel enzymes by recombinant DNA technology is an important prerequisite for the identification of synthetically valuable biocatalysts that allow the development of novel and highly stereoselective pathways for the synthesis of complex carbohydrates and glycoconjugates.

Broadening the range of applications of known enzymes
We study the catalytic mechanism of enzymes by enzymological methods and by X-ray structure determination (collaboration with structural biologists) to facilitate rational modification of the substrate binding pocket by site-directed mutagenesis. The goals are improvements in substrate tolerance, stereoselectivity, and stability of synthetically valuable enzymes.
Darmstadt, Germany
TU Darmstadt | Chemie der PolymerenThe research group of Matthias Rehahn at the Ernst-Berl-Institute for Technical and Macromolecular Chemistry focuses on functional and colloidal polymer systems as well as polymers at interfaces. In addition to transition metal-catalyzed polycondensation processes, controlled and living polymerization processes are used to build these systems.
Darmstadt, Germany
TU Darmstadt | Macromolecular and Paper ChemistryWith a creative team of researchers, we combine polymer science & paper chemistry, to develop innovative and sustainable materials, with fields of application progressing from coatings to construction materials and paper-based microfluidic devices.
Darmstadt, Germany
TU Darmstadt | Smart membranesWe are a dynamic, innovative team searching for new nanoporous materials, manufacturing methods and transport processes with benefits in the areas of water, sensor technology and energy conversion.
Darmstadt, Germany
TU Darmstadt | Biologische ChemieSolid phase synthesis of peptide analogues
Screening of combinatorial libraries
Binding assays and activity tests with chemokine inhibitors
Modification and immobilization of proteins
Structuring of biomolecules on surfaces
Darmstadt, Germany
TU Darmstadt | Konformationssensitive MSWhile it would be ideal to have high-resolution structures available for all proteins, not all are amenable to conventional methods such as X-ray crystallography or nuclear magnetic resonance. These techniques also often capture either a single low-energy state or an "average" conformation and therefore do not accurately reflect the entire conformational space that a protein occupies. Mass spectrometry has evolved to a point where it is a near-universal technique that can provide important structural information about challenging systems. In our lab, we work to develop these methods and also apply them to solve biological questions, often in collaboration with other researchers.
Darmstadt, Germany
TU Darmstadt | Angewandte BiochemieThe interdisciplinary research group combines chemistry, biology and biomolecular engineering. Therefore, the focus is on a broad spectrum of application-oriented research.